Introduction -- Defining pluralism : Simon Pokagon, Ida B. Wells-Barnett, and Thomas fortune -- Evolution and American Indian philosophy -- Feminist resistance : Anna Julia Cooper, Jane Addams, and Charlotte Perkins Gilman -- Labor, empire and the social gospel : Washington Gladden, Walter Rauschenbusch, and Jane Addams -- A new name for an old way of thinking : William James -- Making ideas clear : Charles Sanders Peirce -- The beloved community and its discontents : Josiah Royce and the realists (...) -- War, anarchism, and sex : Emma Goldman and Margaret Sanger -- Democracy and social ethics : John Dewey -- Naturalism and idealism, fear, and conventionality : Mary Whiton Calkins and Elsie Clews Parsons -- Race riots and the color line : W. E. B. du Bois -- Philosophy reacts : Hartley Burr Alexander and Morris R. Cohen -- Creative experience : Mary Parker Follett -- Cultural pluralism : Horace Kallen and Alain Locke -- War and the rise of logical positivism : Otto Neurath and Rudolf Carnap -- Mccarthyism and American empiricism : Jacob Loewenberg, Henry Sheffer, C. I. Lewis, and Charles Morris -- The linguistic turn : Gustav Bergmann, May Brodbeck, and W. V. O. Quine -- Resisting the turn : Donald Davidson, Wilfrid Sellars, and the pluralist rebellion -- Philosophy outside : John Muir, Aldo Leopold, Joseph Wood Krutch, and Rachel Carson -- Economics and technology : Lewis Mumford, C. Wright Mills and John Kenneth Galbraith -- Politics : John Rawls, Robert Nozick, Michael Sandel, Martha Nussbaum, and Noam Chomsky -- Civil rights : Martin Luther King, Jr., Richard Wright and James Baldwin -- Black power : Malcolm X, James Cone, Audre Lorde, Bell Hooks, Angela Davis, and Cornel West -- Latin American American philosophy -- Red power, indigenous philosophy : Vine Deloria, Jr. and contemporary American Indian thought -- Feminism -- Engaged philosophy and the environment -- American philosophy today -- Recovering and sustaining the American tradition -- American philosophy revitalized -- The spirit of American philosophy in the new century. (shrink)

The available evidence indicates that the music of a culture reflects the speech rhythm of the prevailing language. The normalized pairwise variability index (nPVI) is a measure of durational contrast between successive events that can be applied to vowels in speech and to notes in music. Music–language parallels may have implications for the acquisition of language and music, but it is unclear whether native-language rhythms are reflected in children's songs. In general, children's songs exhibit greater rhythmic regularity than adults' songs, (...) in line with their caregiving goals and frequent coordination with rhythmic movement. Accordingly, one might expect lower nPVI values (i.e., lower variability) for such songs regardless of culture. In addition to their caregiving goals, children's songs may serve an intuitive didactic function by modeling culturally relevant content and structure for music and language. One might therefore expect pronounced rhythmic parallels between children's songs and language of origin. To evaluate these predictions, we analyzed a corpus of 269 English and French songs from folk and children's music anthologies. As in prior work, nPVI values were significantly higher for English than for French children's songs. For folk songs (i.e., songs not for children), the difference in nPVI for English and French songs was small and in the expected direction but non-significant. We subsequently collected ratings from American and French monolingual and bilingual adults, who rated their familiarity with each song, how much they liked it, and whether or not they thought it was a children's song. Listeners gave higher familiarity and liking ratings to songs from their own culture, and they gave higher familiarity and preference ratings to children's songs than to other songs. Although higher child-directedness ratings were given to children's than to folk songs, French listeners drove this effect, and their ratings were uniquely predicted by nPVI. Together, these findings suggest that language-based rhythmic structures are evident in children's songs, and that listeners expect exaggerated language-based rhythms in children's songs. The implications of these findings for enculturation processes and for the acquisition of music and language are discussed. (shrink)

Transcription factor (TF) signaling regulates gene transcription and requires a complex network of proteins. This network includes co‐activators, co‐repressors, multiple TFs, histone‐modifying complexes, and the basal transcription machinery. It has been widely appreciated that pioneer factors, such as FoxA1 and GATA1, play an important role in opening closed chromatin regions, thereby allowing binding of a secondary factor. In this review we will focus on a newly proposed model wherein multiple TFs, such as steroid receptors (SRs), can function in a pioneering (...) role. This model, termed dynamic assisted loading, integrates data from widely divergent methodologies, including genome wide ChIP‐Seq, digital genomic footprinting, DHS‐Seq, live cell protein dynamics, and biochemical studies of ATP‐dependent remodeling complexes, to present a real time view of TF chromatin interactions. Under this view, many TFs can act as initiating factors for chromatin landscape programming. Furthermore, enhancer and promoter states are more accurately described as energy‐dependent, non‐equilibrium steady states. (shrink)

Maize develops separate male and female flowers in different locations on a single plant. Male flowers develop at the tip of the shoot in the tassel, and female flowers develop on the ears, which terminate short branches. The development of male flowers in tassels and female flowers in ears is the result of selective abortion of pistils or stamens, respectively, in developing florets. Genetic analysis has shown that stamen abortion and pistil abortion are under the control of two different genetic (...) pathways. Local levels of the plant hormone gibberellic acid determine whether or not stamens are suppressed. Pistil abortion is under the regulation of the tassel seed genes, one of which has been shown to encode a short‐chain alcohol dehydrogenase. The tassel seed genes play a role in regulating the fate of inflorescence meristems as well as pistil primordium fate. (shrink)

Biological and epidemiological phenomena are often measured with error or imperfectly captured in data. When the true state of this imperfect measure is a confounder of an outcome exposure relationship of interest, it was previously widely believed that adjustment for the mismeasured observed variables provides a less biased estimate of the true average causal effect than not adjusting. However, this is not always the case and depends on both the nature of the measurement and confounding. We describe two sets of (...) conditions under which adjusting for a non-deferentially mismeasured proxy comes closer to the unidentifiable true average causal effect than the unadjusted or crude estimate. The first set of conditions apply when the exposure is discrete or continuous and the confounder is ordinal, and the expectation of the outcome is monotonic in the confounder for both treatment levels contrasted. The second set of conditions apply when the exposure and the confounder are categorical. In all settings, the mismeasurement must be non-differential, as differential mismeasurement, particularly an unknown pattern, can cause unpredictable results. (shrink)

Fusion genes formed by chromosomal rearrangements are common drivers of cancer. Recent innovations in the field of next‐generation sequencing (NGS) have seen a dynamic shift from traditional fusion detection approaches, such as visual characterization by fluorescence, to more precise multiplexed methods. There are many different NGS‐based approaches to fusion gene detection and deciding on the most appropriate method can be difficult. Beyond the experimental approach, consideration needs to be given to factors such as the ease of implementation, processing time, associated (...) costs, and the level of expertise required for data analysis. Here, the different NGS‐based methods for fusion gene detection, the basic principles underlying the techniques, and the benefits and limitations of each approach are reviewed. This article concludes with a discussion of how NGS will impact fusion gene detection in a clinical context and from where the next innovations are evolving. (shrink)

Introduction This article is a response to Zagouras, Ellick, and Aulisio who presented a case study justifying the questioning of the capacity and autonomy of a young woman with a physical disability who was pregnant and facing coercive pressure to terminate. Case description Julia is described as a 26-year-old woman with a neurological disability that requires her to receive assistance with activities of daily living. She was described as living with her parents who provided her with personal care assistance. Julia (...) became pregnant and her parents wished her to terminate because they did not want to care for her child in addition to her. In fact, Julia's parents threatened her with institutionalization if she did not elect to terminate the pregnancy. Her health care team questioned her decision-making capacity based on her alleged “mental age” and experiences of being sheltered and excluded. The health care team used directive tactics to convince Julia to terminate the pregnancy, which describe as both an ethical and feminist intervention. Discussion The current authors take issue with the case analysis provided by and argue that they neglected to account for numerous instances of systemic ableism that adversely affected Julia, demonstrated prejudicial and judgmental attitudes toward pregnancy and disability, inappropriately questioned her decision-making capacity by infantilizing her, misconstrued the feminist concept of relational autonomy, and colluded with coercive interference from family members. This is a classic example of discriminatory and culturally incompetent reproductive health care for a disabled woman. (shrink)

Although Archaea inhabit the human body and possess some characteristics of pathogens, there is a notable lack of pathogenic archaeal species identified to date. We hypothesize that the scarcity of disease‐causing Archaea is due, in part, to mutually‐exclusive phage and virus populations infecting Bacteria and Archaea, coupled with an association of bacterial virulence factors with phages or mobile elements. The ability of bacterial phages to infect Bacteria and then use them as a vehicle to infect eukaryotes may be difficult for (...) archaeal viruses to evolve independently. Differences in extracellular structures between Bacteria and Archaea would make adsorption of bacterial phage particles onto Archaea (i.e. horizontal transfer of virulence) exceedingly hard. If phage and virus populations are indeed exclusive to their respective host Domains, this has important implications for both the evolution of pathogens and approaches to infectious disease control. (shrink)

Both target papers cite evidence from infancy and early childhood to support the notion of human musicality as a somewhat static suite of capacities; however, in our view they do not adequately acknowledge the critical role of developmental timing, the acquisition process, or the dynamics of social learning, especially during later periods of development such as middle childhood.

This is an excerpt from the content“Accountability” used to be a term that applied primarily to K-12 education, especially following the passage of No Child Left Behind. However, the recent economic downturn and subsequent recovery prompted debates on whether the cost of pursuing a college degree is “worth it” for students. Students’ post-graduation debt and job market prospects have been publicly scrutinized as well as the operations of large research universities. Supporters of higher education posit that these critiques of the (...) system impose a business model where it should not be as they emphasize outputs and efficiency over quality. At the same time, it is hard to ignore that calls for accountability in higher education are getting louder than ever before.In Accountability, Pragmatic Aims, and the American University, Ana M. Martínez-Alemán examines accountability from a historical perspective, arguing that accountability arose in the American university during the early part of the twentieth century. This rise coin. (shrink)

(2012). A Review of “Contemporary Anarchist Studies: An Introductory Anthology of Anarchy in the Academy”. Educational Studies: Vol. 48, “Anarchism … is a living force within our life …” Anarchism, Education and Alternative Possibilities, pp. 103-107.

Residual confounding is a common source of bias in observational studies. In this article, we build upon a series of sensitivity analyses methods for residual confounding developed by Brumback et al. and Chiba whose sensitivity parameters are constructed to quantify deviation from conditional exchangeability, given measured confounders. These sensitivity parameters are combined with the observed data to produce a “bias-corrected” estimate of the causal effect of interest. We provide important generalizations of these sensitivity analyses, by allowing for arbitrary exposures and (...) a wide range of different causal effect measures, through the specification of the target causal effect as a parameter in a generalized linear model with the arbitrary link function. We show how our generalized sensitivity analysis can be easily implemented with standard software, and how its sensitivity parameters can be calibrated against measured confounders. We demonstrate our sensitivity analysis with an application to publicly available data from a cohort study of behavior patterns and coronary heart disease. (shrink)

Face recognition is one of the most important skills in primate social cognition, enabling the formation of long-lasting, interindividual relationships. This article summarizes existing research on face processing in non-human primates with the goal of understanding the evolution of this important socio-cognitive skill. It describes different levels of configural processing and the importance of early visual expertise in face processing. By reviewing studies on the well-known face inversion effect, evidence for configural face processing in non-human primates is reviewed. The study (...) examines the social salience of faces by employing a variety of gaze tracking and visual orienting techniques. It deals with the ability to recognize individuals across various viewpoints and manipulating configural cues directly. Neuroimaging studies aid in understanding whether the neural correlates of face recognition in non-human primates involve a similar brain regions as humans. (shrink)

In remote regions of the eastern Andaman, into the 1990s, a remarkable rapport with nature's forces was occurring.1 Most strikingly expressed during adolescence, it emerged spontaneously from a local type of consciousness. Both the capability and the underlying consciousness were conceived within a pervasive milieu of lushly sensual infant nurture.2 So dependable was the pattern of affection, it spawned a tactile language long before onset of speech. Speech, learning and sociality then followed in the eros‐driven paradigm already set. So did (...) a rare rapport with nature's forces.With nothing in the culture to discourage it, eros was not walled‐off as children grew. It remained firmly at the root of consciousness on through teens. To be a child out in those seas was to move spontaneously and digressively out into life pursuing sundry passion pulses. When erotic power escalated during adolescence, rapport with natural forces dramatically increased. Spectacular gambolings with nature began bursting forth—sometimes astonishingly complex rhythmic ones. No clouds of moody adolescent angst discouraged spontaneity; no flattening of affect suppressed adolescent verve; no emotional dissimulation confounded purpose. Adolescence was a time for a blossoming of affect, for melding deeply and dynamically with habitat. It was a time to profoundly dance with nature's forces.Possessing a protean character, love lies more fluidly within the human frame than language. Following its own inner protocols, love seems able to evade the stable kinds of labeling required for logical inquiry. In exotic cultures it is hard to see at all. In the eastern Andaman, its workings were initially invisible to Western eyes. It was necessary to firm up subliminal awarenesses before the workings out of eros could even be detected there. Though difficult to deal with scientifically, love plays such a profound role in the affairs of humankind that it begs experimental types of scrutiny.A fracturing of love into Bacchanalian and Sublime occurred during the early Greek foundations of Western culture. Out of that schism Western ethos grew. The ethos molded the Western type of consciousness. In the eastern Andaman, eros was not cleaved at all. It shaped a type of psyche not countenanced by the West since its prehistory. (shrink)

Patents and free trade make strange bedfellows. For most of their history, patents have been instruments deployed to resist trade with other countries, not to enhance it. Whether one looks at Venetian laws that punished citizens who practiced local crafts outside the city, the Mercantilist uses to which patents were put in Elizabethan England, or the cartels of the 19th and 20th centuries created on a foundation of interlocking patent rights, patents have had a distinctly protectionist function. It is thus (...) ironic that it is intellectual property rights in general, and patents in particular, that have been held up in recent years as the poster child of much that is wrong with globalization and free trade. Nowhere is this more so than in debates concerning international human rights law and patents, in particular the position that patents violate an international right to health. (shrink)

It is well-known that dichotomization can cause bias and loss of efficiency in estimation. One can easily construct examples where adjusting for a dichotomized confounder causes bias in causal estimation. There are additional examples in the literature where adjusting for a dichotomized confounder can be more biased than not adjusting at all. The message is clear, do not dichotomize. What is unclear is if there are scenarios where adjusting for the dichotomized confounder always leads to lower bias than not adjusting. (...) We propose several sets of conditions that characterize scenarios where one should always adjust for the dichotomized confounder to reduce bias. We then highlight scenarios where the decision to adjust should be made more cautiously. To our knowledge, this is the first formal presentation of conditions that give information about when one should and potentially should not adjust for a dichotomized confounder. (shrink)

I am often asked how one finds isolated people whose whereabouts or existence is unsure. There is even greater curiosity about how one can join such people in the absence of common customs or spoken language. Moreso about how one makes sense of what one sees under such circumstances. After several years of contact with variously acculturated groups of settled and semi‐settled sea nomads in the Sea of Andaman Moken, Moklen, and Urak Lawoi (and its Lonta subgroup) two out‐of‐the‐blue opportunities (...) unexpectedly occurred to travel with fully nomadic pagan ones, a type no longer thought to exist. The first trip was short, but it prepared me for the long next one. The first was a band of unknown origin, the second an aboriginal Moken‐related group off southern Burma. (shrink)

Taxation and government policy related to it have only episodic appearance in classical Protestant ethical sources. Of the early sixteenth century reformers, Luther gave most attention to the subject, justifying taxation in general as necessary for the just service of government to the public good and calling the princes to spend tax monies for that good rather than their own luxury. Calvin made much the same claims but called more clearly for official church scrutiny of all government than did Luther. (...) Two centuries later John Wesley criticized English tax policy, appealing to standards of economic efficiency and compassion for the poor with little reference overtly to theology. The churches of colonial and post-revolutionary America developed no systematic, theologically rooted rationale for taxation ethics, either; but official Protestant denominational concern for such ethics has grown measurably in the most recent fifteen years. After a survey of these recent national church statements, and on the basis of them and the slender Protestant heritage on this issue, we end by posing four questions which we see as worthy of much serious thinking by contemporary American Protestant ethicists and church bodies. (shrink)

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Efforts by governments, firms, and patients to deliver pioneering drugs for critical health needs face a challenge of diminishing efficiency in developing those medicines. While multi-sectoral collaborations involving firms, researchers, patients, and policymakers are widely recognized as crucial for countering this decline, existing incentives to engage in drug development predominantly target drug manufacturers and thereby do little to stimulate collaborative innovation. In this mini review, we consider the unexplored potential within pharmaceutical regulations to create novel incentives to encourage a diverse (...) set of actors from the public and private spheres to engage in the kind of collaborative knowledge exchange requisite for fostering enhanced innovation in early drug development. (shrink)